Opportunity Information: Apply for PAS 17 064
The grant opportunity titled "Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44)" is a National Institutes of Health (NIH) funding announcement from the National Institute on Aging (NIA) designed specifically for small businesses through the NIH Small Business Innovation Research (SBIR) program. Its core purpose is to push forward practical, innovative research that can be turned into real-world products and services. The focus is on advancing progress in preventing and treating Alzheimer's disease and related dementias, as well as improving the care and treatment of people living with AD/ADRD. In other words, this is a commercialization-oriented research program that is looking for solutions that can move beyond basic science and toward tools, technologies, therapeutics, diagnostics, care platforms, or other applied innovations that could make a measurable impact.
This announcement uses the SBIR grant mechanisms R43 and R44, which generally align with the typical SBIR structure of phased development: early-stage feasibility work followed by more advanced R&D and product development. While the provided text does not lay out the detailed phase rules, the R43/R44 framing signals that applicants are expected to propose a development path that starts with demonstrating that an idea works and can be built, then progresses toward a more mature prototype, validation, or readiness for the next step toward market or deployment. The emphasis on "innovative products and/or services" makes it clear that NIA is not only looking for academic-style research findings, but for deliverables that can ultimately be used by patients, caregivers, clinicians, health systems, or researchers working on AD/ADRD.
Eligibility is limited to small businesses, which is the standard target applicant group for SBIR funding. The announcement also makes several important restrictions about foreign participation. Non-domestic (non-U.S.) entities, meaning foreign institutions, are not eligible to apply. Additionally, non-domestic components of U.S. organizations are also not eligible to apply, which typically means a U.S. company cannot propose to conduct substantial project work through a foreign branch or foreign operating unit in a way that counts as a non-domestic component. At the same time, the notice leaves room for "foreign components" as defined in the NIH Grants Policy Statement to be allowed in some cases, which generally refers to discrete elements of the project being performed outside the U.S. under specific NIH rules and approvals. Practically, the safe interpretation is that the applying organization must be a U.S. small business, and any international involvement would need to fit NIH's formal definition of a foreign component and comply with NIH policy.
Administratively, the opportunity is categorized as discretionary grant funding under the health activity category, with CFDA number 93.866, and it is issued by the National Institutes of Health. The funding opportunity number is PAS 17 064. The record indicates an original closing date of 2019-09-05, a creation date of 2016-12-02, and an expectation of about 20 awards. An award ceiling is not specified in the provided source data, so the maximum award amount is not stated here and would normally be determined by the FOA's detailed budget guidance or standard SBIR limits applicable at the time.
Overall, this FOA is best understood as a targeted SBIR pathway for small businesses that have a credible, development-oriented plan to create new technologies or services that could improve prevention, treatment, or care outcomes in Alzheimer's disease and related dementias. It sits at the intersection of biomedical innovation and product development, encouraging applicants to propose work that can translate into deployable solutions rather than purely exploratory research.Apply for PAS 17 064
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2016-12-02.
- Applicants must submit their applications by 2019-09-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 20 candidate(s).
- Eligible applicants include: Small businesses.
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Frequently Asked Questions (FAQs)
What is the "Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44)" opportunity?
It is a National Institutes of Health (NIH) funding announcement from the National Institute on Aging (NIA) that supports small-business research and development focused on Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD). The opportunity is offered through the NIH Small Business Innovation Research (SBIR) program using the R43 and R44 grant mechanisms.
Which agency and institute are sponsoring this funding opportunity?
The issuing agency is the National Institutes of Health (NIH), and the sponsoring institute is the National Institute on Aging (NIA).
What is the primary purpose of this SBIR funding announcement?
The core purpose is to advance practical, innovative research that can be translated into real-world products and services. The program is commercialization-oriented and aims to move beyond basic science toward applied innovations that can have measurable impact in AD/ADRD prevention, treatment, or care.
What kinds of projects does NIA appear to be looking for under this FOA?
Based on the description provided, NIA is seeking development-focused work that results in innovative products and/or services. Examples mentioned or implied include tools, technologies, therapeutics, diagnostics, care platforms, and other applied innovations that could be used by patients, caregivers, clinicians, health systems, or researchers in the AD/ADRD space.
Is this opportunity focused on research publications or on deliverable products and services?
The emphasis is on deliverables that can ultimately be used in real-world settings. While research is involved, the announcement highlights "innovative products and/or services" and a translation path toward market or deployment rather than purely academic-style findings.
What do the R43 and R44 mechanisms mean in this announcement?
R43 and R44 are SBIR grant mechanisms that generally align with phased development. The framing signals that applicants are expected to propose a development path that begins with early feasibility work (showing the idea works and can be built) and progresses toward more advanced R&D and product development (such as a more mature prototype or validation work).
Does the provided information include detailed Phase I and Phase II rules?
No. The text indicates a typical phased SBIR structure but does not provide detailed phase rules or requirements in the excerpt. The R43/R44 structure is presented as a signal that phased development expectations apply.
Who is eligible to apply for this grant opportunity?
Eligibility is limited to small businesses, consistent with the SBIR program.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply under the information provided.
Can a U.S. small business include a non-domestic component in its application?
The provided information states that non-domestic components of U.S. organizations are not eligible. This typically means a U.S. company cannot propose to conduct substantial project work through a foreign branch or foreign operating unit as a non-domestic component.
Is any international involvement allowed at all?
The notice indicates that "foreign components" (as defined in the NIH Grants Policy Statement) may be allowed in some cases. Any international involvement would need to fit NIH's formal definition of a foreign component and comply with NIH policy.
What is the funding opportunity number for this announcement?
The funding opportunity number is PAS 17 064.
What type of funding is this categorized as?
It is categorized as discretionary grant funding.
What is the activity category associated with this grant?
The activity category is health.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.866.
How many awards are expected?
The record indicates an expectation of about 20 awards.
What is the maximum award amount (award ceiling) for this opportunity?
An award ceiling is not specified in the provided information. The maximum award amount is not stated in the source data excerpt and would typically be found in the detailed FOA budget guidance or applicable SBIR limits for the relevant time period.
What are the key dates mentioned for this opportunity?
The record indicates a creation date of 2016-12-02 and an original closing date of 2019-09-05.
Is this opportunity primarily about basic science or applied development?
It is positioned as applied, commercialization-oriented development. The goal is to support innovations that can translate into deployable solutions for preventing or treating AD/ADRD and improving care and treatment for people living with these conditions.
What outcomes is this program trying to improve in the AD/ADRD field?
The focus is on advancing progress in preventing and treating Alzheimer's disease and related dementias and improving the care and treatment of people living with AD/ADRD.
Who might ultimately benefit from innovations developed under this funding announcement?
The description highlights potential end users and beneficiaries such as patients, caregivers, clinicians, health systems, and researchers working on AD/ADRD.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAS 17 064) also looked into and applied for these:
| Funding Opportunity |
|---|
| Tools for Clinical Care and Management of Alzheimers Disease (AD) and Its Comorbidities (R41/R42) Apply for PAR 17 066 Funding Number: PAR 17 066 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tools for Clinical Care and Management of Alzheimers Disease (AD) and its Comorbidities (R43/R44) Apply for PAR 17 067 Funding Number: PAR 17 067 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pilot Clinical Trials Targeting HIV-1 Reservoirs in Children (U01) Apply for RFA AI 16 086 Funding Number: RFA AI 16 086 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Maximizing Access to Research Careers Undergraduate - Student Training in Academic Research (MARC U-STAR) (T34) Apply for PAR 17 068 Funding Number: PAR 17 068 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| HIV and AIDS Community Grants Program Apply for COMMGRANTSHIVAIDS17 Funding Number: COMMGRANTSHIVAIDS17 Agency: U.S. Mission to South Africa Category: Health Funding Amount: $50,000 |
| Institutional Training Programs to Advance Translational Research on Alzheimers Disease and AD Related Dementias (T32) Apply for RFA AG 17 063 Funding Number: RFA AG 17 063 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Innovative Programs to Enhance Research Training (IPERT) (R25) Apply for PAR 17 070 Funding Number: PAR 17 070 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Development of Multipurpose Prevention Technologies: A Strategy for the Prevention of Sexually Transmitted Infections (STIs) (R61/R33) Apply for RFA AI 16 085 Funding Number: RFA AI 16 085 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Leveraging Electronic Health Records for Alcohol Services Research (R21/R33) Apply for PAR 17 071 Funding Number: PAR 17 071 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Research Centers in Minority Institutions (U54) Apply for RFA MD 17 003 Funding Number: RFA MD 17 003 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Frontotemporal Degeneration FTD Sequencing Consortium: Discovery, replication and validation (UG3/UH3) Apply for RFA NS 17 017 Funding Number: RFA NS 17 017 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Shared Instrumentation Grant (SIG) Program (S10) Apply for PAR 17 074 Funding Number: PAR 17 074 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Utilizing Health Information Technology to Scale and Spread Successful Practice Models Using Patient-reported Outcomes (R18) Apply for PA 17 077 Funding Number: PA 17 077 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: $750,000 |
| Novel Analytical Approaches for Metabolomics Data (R03) Apply for RFA RM 17 001 Funding Number: RFA RM 17 001 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
| Innovations for Healthy Living - Improving Population Health and Eliminating Health Disparities (R43/R44) Apply for RFA MD 17 001 Funding Number: RFA MD 17 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42) Apply for RFA MD 17 002 Funding Number: RFA MD 17 002 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R34) Apply for RFA MH 17 612 Funding Number: RFA MH 17 612 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33) Apply for RFA MH 17 606 Funding Number: RFA MH 17 606 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| High-End Instrumentation (HEI) Grant Program (S10) Apply for PAR 17 076 Funding Number: PAR 17 076 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33) Apply for RFA MH 17 604 Funding Number: RFA MH 17 604 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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