Alzheimer’s Research Program Transforming Care Award | HT942525AZRPTRCA

Opportunity Information: Apply for HT942525AZRPTRCA

The Alzheimer’s Research Program Transforming Care Award (Funding Opportunity Number HT942525AZRPTRCA) is a discretionary grant opportunity offered by the U.S. Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It sits in the Science and Technology / Research and Development category (CFDA 12.420) and is designed to move practical, care-focused Alzheimer’s and dementia research forward by supporting clinical research and clinical trials. The main emphasis is not basic discovery work, but real-world interventions, innovations, and implementable solutions that improve dementia care for people living with Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD), along with the people who support them day to day, described in the announcement as care partners.

A defining feature of this award is its clear, care-delivery orientation. Projects are expected to target “critical areas for dementia care,” which signals an interest in studies that can change how care is provided, experienced, or coordinated, rather than studies focused solely on disease mechanisms. Competitive proposals will likely show a strong link between the intervention being tested and measurable outcomes that matter to both members of the care dyad: the individual with an AD/ADRD diagnosis and their care partner(s). In other words, the program expects applicants to treat caregiving impact as a primary consideration, not an afterthought, and to design the research so it produces actionable knowledge that can be translated into better support, services, or care models.

Community collaboration is a requirement, not an optional enhancement. This means applicants should plan for meaningful engagement with relevant community stakeholders, which could include patient and caregiver groups, community-based organizations, clinics, long-term care settings, public health partners, or other local and regional entities involved in dementia care. The spirit of this requirement is that interventions should be shaped with the people and settings they are meant to serve, increasing feasibility, cultural and practical fit, and the odds that successful approaches can be adopted beyond the study period.

The opportunity also includes a specific structure that supports multiple principal investigators under a Career Initiation or Transition (CIT) Partnership Option. Under this arrangement, only the initiating PI submits the pre-application, but each PI must submit a full application if the project advances. Applicants should pay close attention to the administrative linkage between partnering submissions: the announcement warns that all associated applications for a single research project may be withdrawn if the initiating or partnering application is rejected or administratively withdrawn. Practically, this creates a shared fate across the partnership, so teams using the CIT option need tight coordination on eligibility, compliance, and submission quality and timing across all PIs.

From an applicant standpoint, eligibility is listed as “Unrestricted,” which typically indicates a wide range of organizations and institutions may apply, assuming they can meet the program’s requirements and any standard federal grant conditions. The original closing date is August 29, 2025, and the agency anticipates making about three awards. While the posted source excerpt does not specify an award ceiling amount, the low expected award count suggests a competitive process where proposals need to be sharply aligned to the transforming-care mission, well-justified clinically, and operationally ready to execute.

Overall, this grant is aimed at supporting patient- and caregiver-centered clinical research that can directly improve dementia care through tested interventions and practical innovations, built in collaboration with the community, and with an option for multi-PI partnership structures that are particularly relevant for investigators at career initiation or transition stages.

• The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "Alzheimer’s Research Program Transforming Care Award" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
• This funding opportunity was created on 2025-04-18.
• Applicants must submit their applications by 2025-08-29. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• The number of recipients for this funding is limited to 3 candidate(s).
• Eligible applicants include: Unrestricted.

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