DOD Chronic Pain Management, Clinical Outcomes Research Award | HT9425 23 CPMRP CORA

Opportunity Information: Apply for HT9425 23 CPMRP CORA

The DOD Chronic Pain Management, Clinical Outcomes Research Award (CORA) is a FY23 funding opportunity from the Department of Defense (Department of the Army, U.S. Army Medical Research Acquisition Activity, USAMRAA) aimed at strengthening real-world chronic pain care by supporting late-stage translational clinical outcomes research. The central idea is to move evidence-based chronic pain management approaches into practical clinical use more quickly, so that patients and health systems see measurable improvements in outcomes. Rather than funding early discovery research or brand-new experimental techniques, this program emphasizes evaluating, validating, and implementing approaches that already have a meaningful evidence base, then translating them into tools that can be used in routine care, such as health care products, enabling technologies, clinical practice guidelines, and models of care.

A key expectation is that applications clearly connect the proposed study to changes in clinical practice. Projects are expected to show how the findings will inform the development, refinement, or revision of existing standards of care, recommendations, or guidelines for chronic pain management. In other words, the award is not just about producing publishable results; it is about generating outcomes-focused evidence strong enough to shape what clinicians do, what systems adopt, and how care is organized. The opportunity is explicitly framed around identifying and implementing best practices by analyzing the comparative merits of pain management approaches, with an emphasis on clinical outcomes and practical adoption.

The solicitation also draws a clear boundary around opioids. Proposals that seek to advance new or novel opioid-based therapeutic interventions are considered outside the intent of this mechanism and are not expected to be selected for funding. However, studies that examine opioid use within current prescribing practices, especially work designed to understand opioid utilization and reduce reliance on opioids in chronic pain care, are considered acceptable. This positions the program as supportive of outcomes-based strategies that can improve pain management while addressing opioid-related risks through better implementation of existing evidence and best practices.

Administratively, this is a discretionary federal opportunity (Funding Opportunity Number: HT9425 23 CPMRP CORA) under the Science and Technology and other Research and Development activity category, with CFDA/Assistance Listing number 12.420. The funding instruments listed are Cooperative Agreement and Grant, indicating awards may involve either standard grant support or a more collaborative federal role depending on the final award structure. Eligibility is listed as unrestricted (open to any type of entity), subject to any clarifications provided in the full notice. The opportunity was created on July 3, 2023, with an original closing date of November 9, 2023. The notice lists an expected number of awards as 1, and the award ceiling is shown as 0, which typically signals that the funding limit may be specified elsewhere in the full announcement or determined by program priorities and available funds rather than a single posted cap.

Overall, CORA is best understood as an implementation-and-outcomes driven research mechanism for chronic pain management within the DOD portfolio: it prioritizes late-stage translational work, measurable clinical impact, and evidence strong enough to influence standards of care, while avoiding funding for novel opioid therapeutics and instead allowing research that supports safer, more effective pain care within existing prescribing realities.

• The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Chronic Pain Management, Clinical Outcomes Research Award" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
• This funding opportunity was created on Jul 03, 2023.
• Applicants must submit their applications by Nov 09, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• The number of recipients for this funding is limited to 1 candidate(s).
• Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.

Apply for HT9425 23 CPMRP CORA

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