Opportunity Information: Apply for HT9425 23 CPMRP CORA
The DOD Chronic Pain Management, Clinical Outcomes Research Award (CORA) is a FY23 funding opportunity from the Department of Defense (Department of the Army, U.S. Army Medical Research Acquisition Activity, USAMRAA) aimed at strengthening real-world chronic pain care by supporting late-stage translational clinical outcomes research. The central idea is to move evidence-based chronic pain management approaches into practical clinical use more quickly, so that patients and health systems see measurable improvements in outcomes. Rather than funding early discovery research or brand-new experimental techniques, this program emphasizes evaluating, validating, and implementing approaches that already have a meaningful evidence base, then translating them into tools that can be used in routine care, such as health care products, enabling technologies, clinical practice guidelines, and models of care.
A key expectation is that applications clearly connect the proposed study to changes in clinical practice. Projects are expected to show how the findings will inform the development, refinement, or revision of existing standards of care, recommendations, or guidelines for chronic pain management. In other words, the award is not just about producing publishable results; it is about generating outcomes-focused evidence strong enough to shape what clinicians do, what systems adopt, and how care is organized. The opportunity is explicitly framed around identifying and implementing best practices by analyzing the comparative merits of pain management approaches, with an emphasis on clinical outcomes and practical adoption.
The solicitation also draws a clear boundary around opioids. Proposals that seek to advance new or novel opioid-based therapeutic interventions are considered outside the intent of this mechanism and are not expected to be selected for funding. However, studies that examine opioid use within current prescribing practices, especially work designed to understand opioid utilization and reduce reliance on opioids in chronic pain care, are considered acceptable. This positions the program as supportive of outcomes-based strategies that can improve pain management while addressing opioid-related risks through better implementation of existing evidence and best practices.
Administratively, this is a discretionary federal opportunity (Funding Opportunity Number: HT9425 23 CPMRP CORA) under the Science and Technology and other Research and Development activity category, with CFDA/Assistance Listing number 12.420. The funding instruments listed are Cooperative Agreement and Grant, indicating awards may involve either standard grant support or a more collaborative federal role depending on the final award structure. Eligibility is listed as unrestricted (open to any type of entity), subject to any clarifications provided in the full notice. The opportunity was created on July 3, 2023, with an original closing date of November 9, 2023. The notice lists an expected number of awards as 1, and the award ceiling is shown as 0, which typically signals that the funding limit may be specified elsewhere in the full announcement or determined by program priorities and available funds rather than a single posted cap.
Overall, CORA is best understood as an implementation-and-outcomes driven research mechanism for chronic pain management within the DOD portfolio: it prioritizes late-stage translational work, measurable clinical impact, and evidence strong enough to influence standards of care, while avoiding funding for novel opioid therapeutics and instead allowing research that supports safer, more effective pain care within existing prescribing realities.Apply for HT9425 23 CPMRP CORA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Chronic Pain Management, Clinical Outcomes Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jul 03, 2023.
- Applicants must submit their applications by Nov 09, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DOD Chronic Pain Management, Clinical Outcomes Research Award (CORA) (FY23)
What is the DOD Chronic Pain Management, Clinical Outcomes Research Award (CORA)?
The DOD Chronic Pain Management, Clinical Outcomes Research Award (CORA) is an FY23 Department of Defense funding opportunity that supports late-stage translational clinical outcomes research aimed at strengthening real-world chronic pain care. The program emphasizes moving evidence-based chronic pain management approaches into routine clinical practice faster, with measurable improvements for patients and health systems.
Which agency is offering this opportunity?
This opportunity is offered by the Department of Defense (Department of the Army), through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the main goal of CORA?
The central goal is to accelerate the practical clinical use of evidence-based chronic pain management approaches by evaluating, validating, and implementing methods that already have a meaningful evidence base, so that clinical outcomes improve in real-world care settings.
What type of research does CORA fund?
CORA supports late-stage translational clinical outcomes research. The focus is on evaluating, validating, and implementing approaches with existing evidence, rather than conducting early discovery research or developing brand-new experimental techniques.
Does CORA fund early-stage or discovery research?
No. The opportunity is positioned as implementation-and-outcomes driven and emphasizes later-stage translational work rather than early discovery research.
Does CORA support development of brand-new experimental pain management techniques?
The program is not intended to fund brand-new experimental techniques. It prioritizes approaches that already have a meaningful evidence base and are ready to be tested, validated, and implemented in practical clinical settings.
What outcomes are expected from funded projects?
Projects are expected to produce outcomes-focused evidence that can drive changes in clinical practice and real-world adoption. The intent is to generate evidence strong enough to influence what clinicians do, what systems adopt, and how care is organized, rather than only producing publishable findings.
How should an application connect to clinical practice?
Applications are expected to clearly connect the proposed study to changes in clinical practice. Projects should show how findings will inform the development, refinement, or revision of existing standards of care, recommendations, or clinical practice guidelines for chronic pain management.
What does "late-stage translational" mean in this program context?
In this program, late-stage translational work means taking evidence-based chronic pain management approaches and translating them into practical tools and practices that can be used routinely in clinical care, with measurable effects on clinical outcomes.
What kinds of deliverables or real-world products does CORA aim to support?
The opportunity highlights translation into tools usable in routine care, such as health care products, enabling technologies, clinical practice guidelines, and models of care.
Is comparative evaluation of pain management approaches relevant to CORA?
Yes. The solicitation is framed around identifying and implementing best practices by analyzing the comparative merits of pain management approaches, with an emphasis on clinical outcomes and practical adoption.
What is CORA's position on opioid-focused research?
The solicitation draws a clear boundary: proposals that seek to advance new or novel opioid-based therapeutic interventions are outside the intent of the mechanism and are not expected to be selected for funding.
Are any opioid-related studies allowed under CORA?
Yes. Studies examining opioid use within current prescribing practices are considered acceptable, especially research designed to understand opioid utilization and reduce reliance on opioids in chronic pain care.
Is this a discretionary grant opportunity?
Yes. The notice describes it as a discretionary federal opportunity.
What is the Funding Opportunity Number for CORA?
The Funding Opportunity Number is HT9425 23 CPMRP CORA.
What is the CFDA/Assistance Listing number associated with this opportunity?
The CFDA/Assistance Listing number is 12.420.
What activity category is listed for this opportunity?
The activity category is listed as Science and Technology and other Research and Development.
What funding instruments are used for CORA awards?
The listed funding instruments are Cooperative Agreement and Grant. This indicates awards may be structured either as standard grant support or as a cooperative agreement involving a more collaborative federal role, depending on the final award structure.
Who is eligible to apply?
Eligibility is listed as unrestricted (open to any type of entity), subject to any clarifications provided in the full notice.
When was this opportunity created?
The opportunity was created on July 3, 2023.
What was the original closing date?
The original closing date listed is November 9, 2023.
How many awards does the notice expect to make?
The notice lists an expected number of awards as 1.
What is the award ceiling for CORA?
The award ceiling is shown as 0, which typically signals that the funding limit may be specified elsewhere in the full announcement or may be determined by program priorities and available funds rather than a single posted cap.
Is CORA mainly about publishing research findings?
No. While research results may be publishable, the program explicitly emphasizes generating outcomes-focused evidence that can shape clinical practice, adoption by health systems, and organization of care.
How should CORA be summarized in plain terms?
CORA is an implementation-and-outcomes driven DOD research mechanism for chronic pain management that prioritizes late-stage translational work, measurable clinical impact, and evidence strong enough to influence standards of care, while avoiding funding for novel opioid therapeutics and supporting studies that help improve opioid prescribing realities through better use of existing evidence and best practices.
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