Opportunity Information: Apply for RFA HL 18 011
The grant opportunity titled "Limited Competition: Genomics and Informatics Center for the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) (U24)" is a National Institutes of Health (NIH) funding announcement from the Department of Health and Human Services, specifically under NIH and associated with CFDA 93.838 (a heart, lung, and blood-related assistance listing). It is issued as a cooperative agreement (U24), which typically means the NIH will have substantial involvement in the project beyond standard grant oversight. The focus of the award is not to launch a new COPD cohort study, but to sustain and operate the centralized infrastructure that supports the broader SPIROMICS research program, including its ongoing and future scientific activities.
This is a limited competition, meaning eligibility is restricted. Only the institution that is already serving as the SPIROMICS Genomics and Informatics Center (GIC) site is allowed to apply. While the general eligible applicant category is listed as public and state-controlled institutions of higher education, the practical effect of the FOA is that the competition is effectively single-site, with a single expected award. The announcement anticipates one award with an award ceiling of $950,000.
The purpose of the funded center is to provide core, program-wide coordination and operational backbone services for SPIROMICS. The awardee is expected to handle overall coordination across the program, maintain and manage study data, and support genomics and informatics functions that enable consistent, high-quality use of SPIROMICS information by the research community. A major component of the work is data management, which includes stewardship of datasets produced under SPIROMICS contracts, ensuring data integrity and usability over time, and enabling appropriate access and use for approved analyses and related projects.
Another central responsibility is biorepository management. This includes oversight, tracking, and maintenance of biospecimens collected as part of SPIROMICS, along with the systems and procedures that ensure specimens remain well-characterized, properly stored, and linked to relevant participant and clinical data in a way that supports future research. Because biospecimens and associated genomic data can raise sensitive ethical and compliance considerations, the FOA also highlights regulatory support as part of the center's role. This can include maintaining compliance documentation, supporting data sharing and specimen use policies, and coordinating requirements tied to human subjects protections and any applicable governance processes.
The center is also expected to provide statistical and analytical support for SPIROMICS, which implies responsibility for supporting robust, consistent analytic approaches across projects, helping coordinate analyses that use SPIROMICS data, and ensuring that methods and outputs are reliable and comparable across studies. In addition, the awardee must provide operational support, which covers the practical day-to-day functions required to keep the program running smoothly, coordinate communications among stakeholders, and support timelines and deliverables across the SPIROMICS enterprise.
Beyond maintaining existing resources, the FOA emphasizes coordination of ongoing and future SPIROMICS-related projects and ancillary studies. In practice, this means the GIC serves as a hub that helps integrate add-on projects with the main SPIROMICS data and specimen resources, supports consistent procedures, and ensures that new work can build on the existing infrastructure without fragmenting systems or duplicating effort. The awardee is responsible for oversight and maintenance of both data and biospecimens collected under prior SPIROMICS contracts, signaling that the center must preserve continuity and long-term usability of these assets.
A notable requirement is participant retention and endpoint assessment support. The FOA specifies that SPIROMICS participants must continue to be contacted regularly, which indicates the center has responsibilities tied to maintaining longitudinal engagement so that follow-up information can be collected, endpoints can be assessed accurately, and the value of the cohort is preserved over time. This ongoing contact function is crucial for longitudinal studies in chronic diseases like COPD, where tracking outcomes and changes over time is often central to the scientific aims.
Key administrative details include the funding opportunity number RFA-HL-18-011, a creation date of March 13, 2017, and an original closing date of June 20, 2017. The funding activity category is health, and the mechanism is explicitly a cooperative agreement, reinforcing that NIH program staff are likely to collaborate closely with the awardee in managing expectations, coordinating with other SPIROMICS components, and ensuring the infrastructure meets program needs. Overall, the FOA is designed to keep the SPIROMICS Genomics and Informatics Center functioning as the central coordinating and stewardship entity for SPIROMICS data, biospecimens, analytics, regulatory compliance, and participant follow-up, ensuring the program remains productive and scientifically valuable for current and future COPD research.Apply for RFA HL 18 011
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Genomics and Informatics Center for the SubPopulations and InteRmediate Outcomes Measures In COPD Study (SPIROMICS) (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838.
- This funding opportunity was created on Mar 13, 2017.
- Applicants must submit their applications by Jun 20, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $950,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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