Opportunity Information: Apply for PAR 19 290
The NCI Research Specialist (Core-based Scientist) Award (R50, Clinical Trial Not Allowed) is a National Institutes of Health funding opportunity from the National Cancer Institute designed to support highly skilled scientists who play essential roles in cancer research programs but are not pursuing a fully independent principal investigator path. The focus is on core facilities, shared resources, and centralized scientific support roles that underpin and enable NCI-funded research across basic, translational, clinical, and population science areas. In practice, this mechanism is meant for the kind of expert who develops, runs, and continuously improves specialized platforms, methods, and services that many projects rely on, such as genomics, proteomics, imaging, biostatistics, bioinformatics, biobanking, flow cytometry, pathology support, or other centralized capabilities that keep a broader cancer research program productive and competitive.
A central goal of the R50 is career stability for these specialists. Many core and shared-resource scientists are critical to the success of multiple grants yet can be vulnerable to shifting project funding because their salaries are often tied to other investigators awards. This FOA aims to reduce that dependence by providing dedicated support for the specialist, along with enough professional autonomy to continue developing expertise, optimizing technologies, maintaining high-quality operations, and contributing intellectually to an established NCI-funded cancer research environment. The award is therefore positioned as a way to retain exceptional technical and scientific talent in the biomedical workforce and to strengthen institutional research infrastructure by keeping core expertise stable over time.
The announcement makes clear that clinical trials are not allowed under this particular R50 opportunity. While the supported work can be connected to clinical research broadly (for example, providing laboratory or analytical support to clinical studies), the award itself cannot propose or conduct a clinical trial as part of the funded activities. Applicants should be prepared to frame the specialist role and planned work around research support, technology development, data generation, analysis pipelines, quality systems, or other core-driven scientific contributions that do not constitute a clinical trial.
Eligibility for applicant organizations is broad and includes many types of U.S.-based entities. Examples listed include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and other eligible organizations. The FOA also explicitly notes inclusion of Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it draws a firm boundary around foreign involvement: non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined by NIH policy) are not allowed.
From the source details, this is a discretionary grant program categorized under Education and Health, and it aligns with multiple CFDA numbers associated with NCI cancer research support (93.393 through 93.399). The funding opportunity number is PAR-19-290, and the original closing date shown in the record is October 18, 2019 (with a creation date of June 5, 2019). No award ceiling or expected number of awards is specified in the provided source snippet, which typically means applicants need to consult the full FOA text and NIH policy references for budget structure, project period expectations, and any program-specific limits.
Overall, this R50 opportunity is best understood as an NCI mechanism to professionalize and stabilize long-term careers for core-based and shared-resource scientists whose work is foundational to cancer research programs. It funds the specialist rather than creating a pathway to independent R01-style leadership, and it is structured to ensure that institutions can retain and empower the experts who keep advanced methods, platforms, and centralized scientific services running at the level modern cancer research demands.Apply for PAR 19 290
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NCI Research Specialist (Core-based Scientist) Award (R50 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.397, 93.398, 93.399.
- This funding opportunity was created on 2019-06-05.
- Applicants must submit their applications by 2019-10-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (PAR 19 290) also looked into and applied for these:
| Funding Opportunity |
|---|
| NCI Research Specialist (Laboratory-based Scientist) Award (R50 Clinical Trial Not Allowed) Apply for PAR 19 291 Funding Number: PAR 19 291 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Development of Clinical Outcome Assessments for Clinical Trials in Substance Use Disorders as FDA-qualified Drug Development Tools (U01 Clinical Trial Optional) Apply for RFA DA 20 015 Funding Number: RFA DA 20 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R21 - Clinical Trials Not Allowed) Apply for RFA DA 20 009 Funding Number: RFA DA 20 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R01 - Clinical Trials Not Allowed) Apply for RFA DA 20 008 Funding Number: RFA DA 20 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Novel Technology Tools to Facilitate Research Using Next Generation Patient-derived Cancer Models (U01 Clinical Trial Not Allowed) Apply for RFA CA 19 055 Funding Number: RFA CA 19 055 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Cancer Prevention Clinical Trials Network (CP-CTNet): CP-CTNet Sites (UG1 Clinical Trial Required) Apply for RFA CA 19 031 Funding Number: RFA CA 19 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control (R21 Clinical Trial Optional) Apply for PAR 19 309 Funding Number: PAR 19 309 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Behavioral Science Track Award for Rapid Transition (B/Start)(R03 Clinical Trial Optional) Apply for PAR 19 310 Funding Number: PAR 19 310 Agency: National Institutes of Health Category: Education, Health Funding Amount: $75,000 |
| Leveraging Big Data Science to Elucidate the Neural Mechanisms of Addiction and Substance Use Disorder (R01 - Clinical Trials Not Allowed) Apply for RFA DA 20 006 Funding Number: RFA DA 20 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Leveraging Big Data Science to Elucidate the Neural Mechanisms of Addiction and Substance Use Disorder (R21 - Clinical Trials Not Allowed) Apply for RFA DA 20 007 Funding Number: RFA DA 20 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Modeling HIV Neuropathology Using Microglia from Human iPSC and Cerebral Organoids (R01 Clinical Trial Not Allowed) Apply for RFA DA 20 023 Funding Number: RFA DA 20 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| The NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) Apply for RFA CA 19 057 Funding Number: RFA CA 19 057 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Strategic Alliances for Medications Development to Treat Substance Use Disorders (R01-Clinical Trial Optional) Apply for PAR 19 318 Funding Number: PAR 19 318 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Participant Engagement and Cancer Genome Sequencing (PE-CGS): Research Centers (U2C Clinical Trial Optional) Apply for RFA CA 19 045 Funding Number: RFA CA 19 045 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| Participant Engagement and Cancer Genome Sequencing (PE-CGS): Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA CA 19 046 Funding Number: RFA CA 19 046 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional) Apply for PAR 19 325 Funding Number: PAR 19 325 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Palliative Care in Home and Community Settings (R21 Clinical Trial Optional) Apply for PAR 19 320 Funding Number: PAR 19 320 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Reducing Stigma to Improve HIV/AIDS Prevention, Treatment and Care in Low- and Middle-Income Countries (R21 Clinical Trial Optional) Apply for PAR 19 326 Funding Number: PAR 19 326 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Palliative Care in Home and Community Settings (R01 Clinical Trial Optional) Apply for PAR 19 321 Funding Number: PAR 19 321 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Grand Opportunity in Medications Development for Substance-Use Disorders (U01 Clinical Trial Optional) Apply for PAR 19 327 Funding Number: PAR 19 327 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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