Opportunity Information: Apply for RFA ES 17 009
The funding opportunity titled "Population-Based Model Organism Research for G x E Exploration in Complex Disease Outcomes (R01 Clinical Trial Not Allowed)" (RFA-ES-17-009) is a National Institutes of Health (NIH) discretionary grant program designed to support environmental health science and toxicology research that relies on population-based model organism resources. The core scientific focus is on gene by environment (G x E) interactions and how environmental exposures combine with genetic variation and epigenetic regulation to influence complex disease outcomes that matter for human health. Projects are expected to use model organisms in a population-based way, meaning the work should leverage genetically diverse panels or populations rather than single inbred strains, with the goal of identifying and understanding why some hosts are more susceptible or more resilient to environmental insults. A central theme is connecting exposure-related biological responses to mechanisms that can plausibly inform human disease risk, progression, or variability in outcomes.
This FOA emphasizes the interplay among environment, genetics, and epigenetics. In practical terms, that means applicants are encouraged to design studies that do more than measure an exposure effect in isolation. Competitive projects typically would examine how genetic background shapes responses to environmental agents, how epigenetic changes may mediate or modify those responses, and how these layers of biology help explain differences in disease-relevant traits across a population. The environmental health and toxicology framing suggests interest in real-world exposure questions, including how chemical, physical, or other environmental stressors influence biological pathways and contribute to complex, multifactorial diseases. The ultimate intent is to use the experimental strengths of model organisms and the statistical power of population-based designs to uncover mechanisms and susceptibility factors that are hard to disentangle in humans alone.
The mechanism is an R01 research project grant, and clinical trials are not allowed under this announcement. That restriction signals that the work should be non-clinical in the human-interventional sense, with the science centered on model organism research and mechanistic investigation rather than testing interventions in people. The activity category is listed under Environment and Health, and the associated CFDA number is 93.113, which aligns with environmental health-related NIH funding (commonly associated with the National Institute of Environmental Health Sciences).
Eligibility is broad and includes many types of domestic organizations and certain non-domestic entities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations (including those other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories as specified); for-profit organizations other than small businesses; and small businesses. The announcement also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). Taken together, this indicates NIH is open to a wide range of institutions, including those serving underrepresented or special populations, and is not limiting participation to a narrow academic subset.
Key administrative details provided in the source data include the original closing date of 2018-02-01 and a creation date of 2017-09-21. The award ceiling is listed as $499,999, indicating an upper limit on the amount that can be requested or awarded under this particular opportunity (as captured in the listing). The expected number of awards is not specified in the supplied data. The funding instrument type is a grant, consistent with the R01 mechanism, and the opportunity is categorized as discretionary, which is typical for NIH research funding announcements.
Overall, this FOA is aimed at researchers who can bring together population genetics in model organisms, rigorous exposure biology, and modern epigenetic or systems-level approaches to explain variation in disease-related outcomes. The most aligned proposals are those that can use genetically diverse model organism populations to pinpoint susceptibility loci or pathways, clarify biological mechanisms linking exposures to adverse outcomes, and generate insights that strengthen understanding of human disease variability in the context of environmental exposures.Apply for RFA ES 17 009
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Population-Based Model Organism Research for G x E Exploration in Complex Disease Outcomes (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113.
- This funding opportunity was created on 2017-09-21.
- Applicants must submit their applications by 2018-02-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $499,999.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA ES 17 009) also looked into and applied for these:
| Funding Opportunity |
|---|
| Immuno-Oncology Translational Network (IOTN): Cancer Immunotherapy Research Projects (U01) Apply for RFA CA 17 045 Funding Number: RFA CA 17 045 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $500,000 |
| Outstanding New Environmental Scientist (ONES) Award (R01 Clinical Trial Optional) Apply for RFA ES 18 001 Funding Number: RFA ES 18 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Environmental Health Sciences Core Centers (EHS CC) (P30 Clinical Trial Optional) Apply for RFA ES 18 003 Funding Number: RFA ES 18 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Required) Apply for PAR 18 261 Funding Number: PAR 18 261 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Not Allowed) Apply for PAR 18 291 Funding Number: PAR 18 291 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| The Role of the Microbiome in the Developmental Origins of Health and Disease (DOHaD) (R01 Clinical Trial Not Allowed) Apply for RFA ES 18 005 Funding Number: RFA ES 18 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Clinical Trial Not Allowed) Apply for RFA ES 18 004 Funding Number: RFA ES 18 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $600,000 |
| SBIR E-learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 18 006 Funding Number: RFA ES 18 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| Exposure Analysis Services for the Environmental Influences on Child Health Outcomes (ECHO) Program (Admin Supp - Clinical Trial Not Allowed) Apply for PA 18 783 Funding Number: PA 18 783 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Novel Approaches for Characterizing Exposure and Response to Engineered Nanomaterials (R43 Clinical Trials Not Allowed) Apply for RFA ES 18 008 Funding Number: RFA ES 18 008 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43)(Clinical Trial Optional) Apply for PAR 18 901 Funding Number: PAR 18 901 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Telomeres as Sentinels of Environmental Exposures, Psychosocial Stress, and Disease Susceptibility: A Methods Comparison Study (U01 Clinical Trial Optional) Apply for RFA AG 19 023 Funding Number: RFA AG 19 023 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $200,000 |
| Research Network on Telomeres as Sentinels of Environmental Exposures, Psychosocial Stress, and Disease Susceptibility (U24 Clinical Trial Not Allowed) Apply for RFA AG 19 022 Funding Number: RFA AG 19 022 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $345,000 |
| Human Health Exposure Analysis Resource: Data Repository, Analysis and Science Center (U2C Clinical Trial Not Allowed) Apply for RFA ES 18 014 Funding Number: RFA ES 18 014 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $1,700,000 |
| Human Health Exposure Analysis Resource: Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA ES 18 010 Funding Number: RFA ES 18 010 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Human Health Exposure Analysis Resource: UnTargeted Exposure Analysis Laboratories (U2C Clinical Trial Not Allowed) Apply for RFA ES 18 012 Funding Number: RFA ES 18 012 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $1,500,000 |
| Human Health Exposure Analysis Resource: Targeted Exposure Analysis Laboratories (U2C Clinical Trial Not Allowed) Apply for RFA ES 18 011 Funding Number: RFA ES 18 011 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $1,500,000 |
| Human Health Exposure Analysis Resource: Environmental Exposure Analysis Laboratories (U2C Clinical Trial Not Allowed) Apply for RFA ES 18 013 Funding Number: RFA ES 18 013 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $700,000 |
| Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts (R24 Clinical Trial Not Allowed) Apply for RFA ES 18 009 Funding Number: RFA ES 18 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $250,000 |
| Virtual Consortium for Translational/Transdisciplinary Environmental Research (ViCTER) (R01 Clinical Trial Optional) Apply for RFA ES 18 007 Funding Number: RFA ES 18 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
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