Opportunity Information: Apply for PAR 17 454
The grant opportunity titled "Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01)" (Funding Opportunity Number PAR-17-454) is a discretionary National Institutes of Health (NIH) research grant that supports systems developmental biology projects. In this FOA, systems developmental biology is framed as research that explains embryonic development by looking at how multiple biological components interact and work together to generate complex developmental outcomes, rather than studying single genes, pathways, or isolated processes in a vacuum. The overarching scientific emphasis is on integrative, multi-component approaches that can clarify how embryos build organs and body structures over time, and how disruptions in those coordinated processes can lead to structural birth defects.
The program is positioned within the NIH health research portfolio (CFDA 93.865; activity category: Health, Income Security and Social Services) and uses the R01 mechanism, meaning it is intended for substantial, hypothesis-driven research projects that can sustain a full research plan rather than a small pilot. The stated purpose specifically highlights understanding embryonic development and the "ontogeny" of structural birth defects, pointing to studies that trace how a defect arises across developmental time and across scales, from molecular and cellular interactions up through tissues and organ systems. In practical terms, competitive projects under this umbrella typically rely on combining datasets and methods (for example, multi-omics, imaging, lineage tracing, quantitative modeling, network or pathway integration, and computational simulations) to explain emergent developmental behaviors and failure modes that result in congenital structural anomalies.
Eligibility is broad and intentionally inclusive. Standard eligible applicants listed include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations that are not federally recognized tribal governments; nonprofits with or without 501(c)(3) status (excluding institutions of higher education under those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other types of applicants. The FOA also explicitly calls out additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISI); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible federal government agencies; faith-based or community-based organizations; Indian/Native American Tribal Governments other than federally recognized; U.S. territories or possessions; regional organizations; and non-U.S. entities (foreign organizations). This range suggests NIH interest in drawing systems-level developmental biology expertise from a wide variety of institutional settings, including organizations that serve underrepresented communities and partners located outside the United States when scientifically justified.
From the administrative details provided, the FOA was created on 2017-08-08, with an original closing date listed as 2019-12-06. The award ceiling is shown as $499,999, indicating an upper limit on award size in the source data (though NIH budgeting can vary by institute, scope, and year, and applicants usually align requested budgets to the proposed work and NIH policy). The "ExpectedAwards" field is not populated in the provided record, so no specific number of anticipated awards is available from this source extract.
In short, PAR-17-454 supports R01-level research that takes a systems perspective on embryonic development, aiming to explain how interacting biological parts collectively drive normal formation of structures and how breakdowns in those interactions produce structural birth defects. It is an NIH grant opportunity with a wide applicant pool spanning academia, government, nonprofit, community-based and faith-based organizations, tribal entities, minority-serving institutions, U.S. territories, regional organizations, and foreign organizations, reflecting a deliberate effort to widen participation in high-impact developmental biology research.Apply for PAR 17 454
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2017-08-08.
- Applicants must submit their applications by 2019-12-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $499,999.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Health, Income Security and Social Services
Next opportunity: Population-Based Model Organism Research for G x E Exploration in Complex Disease Outcomes (R01 Clinical Trial Not Allowed)
Previous opportunity: English Language Grants Competition
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 17 454
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 17 454) also looked into and applied for these:
| Funding Opportunity |
|---|
| Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) (UG3/UH3) Apply for RFA HD 18 032 Funding Number: RFA HD 18 032 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Typical and Atypical Patterns of Language and Literacy in Dual Language Learners (R21-Clinical Trial Optional) Apply for PA 18 328 Funding Number: PA 18 328 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Typical and Atypical Patterns of Language and Literacy in Dual Language Learners (R01-Clinical Trial Optional) Apply for PA 18 316 Funding Number: PA 18 316 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Understanding the Early Development of the Immune System (R01 - Clinical Trial Not Allowed) Apply for PAR 18 333 Funding Number: PAR 18 333 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $300,000 |
| Outcome Measures for Use in Treatment Trials of Individuals with Intellectual and Developmental Disabilities (R01- Clinical Trial Optional) Apply for PAR 18 039 Funding Number: PAR 18 039 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $499,999 |
| Advancing Understanding, Prevention, and Management of Infections Transmitted from Women to their Infants (R01 Clinical Trial Optional) Apply for PA 18 031 Funding Number: PA 18 031 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Studies at Periviable Gestation (R03 Clinical Trial Optional) Apply for PA 18 053 Funding Number: PA 18 053 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Studies at Periviable Gestation (R01 Clinical Trial Optional) Apply for PA 18 036 Funding Number: PA 18 036 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Advancing Understanding, Prevention and Management of Infections Transmitted from Women to their Infants (R21 Clinical Trial Optional) Apply for PA 18 092 Funding Number: PA 18 092 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Studies at Periviable Gestation (R21 Clinical Trial Optional) Apply for PA 18 097 Funding Number: PA 18 097 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Characterization of the Adolescent Reproductive Transition (R01 Clinical Trial Optional) Apply for PA 18 033 Funding Number: PA 18 033 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Safety and Outcome Measures of Pain Medications Used in Children and Pregnant Women (R01 Clinical Trial Optional) Apply for PA 18 038 Funding Number: PA 18 038 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Safety and Outcome Measures of Pain Medications Used in Children and Pregnant Women (R21 Clinical Trial Optional) Apply for PA 18 043 Funding Number: PA 18 043 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Characterization of the Adolescent Reproductive Transition (R21 Clinical Trial Optional) Apply for PA 18 045 Funding Number: PA 18 045 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Characterization of the Adolescent Reproductive Transition (R03 Clinical Trial Optional) Apply for PA 18 046 Funding Number: PA 18 046 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Safety and Outcome Measures of Pain Medications Used in Children and Pregnant Women (R03 Clinical Trial Optional) Apply for PA 18 044 Funding Number: PA 18 044 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Academic Research Enhancement Award (R15 Clinical Trial Required) Apply for PA 18 343 Funding Number: PA 18 343 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $300,000 |
| Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R01 Clinical Trial Optional) Apply for PAR 18 091 Funding Number: PAR 18 091 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R21 Clinical Trial Optional) Apply for PAR 18 094 Funding Number: PAR 18 094 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Multidisciplinary Research in Vulvodynia (R01 Clinical Trial Optional) Apply for PA 18 089 Funding Number: PA 18 089 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 17 454", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.